Institutionen för medicinska vetenskaper, Klinisk fysiologi, Uppsala Universitet.
Titel: "Ventilation and Lung Volume During Sleep and in Obstructive Sleep Apnea"
Disputation: Fredag 9/5 2003 kl. 09.15 i Robergsalen, Akademiska Sjukhuset, ing. 40, 4 tr., Uppsala.
Fakultetsopponent: Docent Karl Franklin, NUS, Umeå Universitetssjukhus
Avhandlingar från Uppsala universitet
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Författare: Appelberg, Jonas
Titel: Ventilation and Lung Volume During Sleep and in Obstructive Sleep Apnea
Institution: Institutionen för medicinska vetenskaper, Klinisk fysiologi
URI: urn:nbn:se:uu:diva-3363
Publikationstyp: Doktorsavhandling
Språk: Engelska
Nyckelord: Sleep, Ventilation, Sleep apnea syndromes, Snoring, Lung volume, Respiration, Computed tomography, Ventilatory response, Ventilation-perfusion, Airway closure
Disputation: 2003-05-09, Robergsalen, Akademiska sjukhuset, 09:15
Opponent: Franklin, Karl, Docent, Lungmedicin, Umeå
Abstract: Obstructive sleep apnea (OSA) appears to affect up to 5% of the population. The extent to what pulmonary function awake and during sleep relates to obstructive breathing and hypoxemia during sleep in these patients is unclear. The aim of this study was to investigate respiratory function in patients with varying degree of snoring and OSA and to analyse regional lung aeration during sleep.
In all, 35 healthy subjects and 90 patients with snoring and OSA were studied. The ventilatory response to CO2 (VRCO2) was measured. Lung function tests were performed. A technique based on computed tomography was developed to study lung aeration during sleep.
Patients with OSA displayed a higher VRCO2 in comparison to healthy subjects and snorers (p<0.01). Increased closing volume and reduced expiratory reserve volume (ERV) were found in patients with OSA (p<0.001). In a multiple regression analysis, ERV was an independent predictor of nocturnal apnea (R2=0.13; p=0.001) and desaturation frequency (R2=0.11; p<0.01). In both healthy subjects and OSA patients, lung aeration was reduced during sleep by 0.10 ml gas/g tissue in the dorsal lung region (p<0.05 and p<0.01). OSA patients had a significantly lower gas/tissue ratio in comparison to healthy subjects both awake (-23%; p<0.04) and during sleep (-25%; p<0.04). In a univariate analysis, functional residual capacity (FRC) correlated with the change in lung aeration from wakefulness to sleep (r=-0.78; p<0.001). In patients with OSA, ERV (r=-0.69; p<0.05) and sleep time (r=0.69; p<0.05) correlated with the fall in lung aeration.
In conclusion, patients with OSA display an increased ventilatory response to CO2, reduced ERV and increased closing volume. ERV predicts nocturnal apnea and desaturation frequency to a similar extent as obesity. Lung aeration is reduced in the dorsal region during sleep and patients with OSA display a lower amount of gas in comparison to healthy subjects. Decrease in lung volumes, promoting airway closure, and loss of muscle tone contributed to the altered lung function during sleep.
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Beställ: Köp boken via Acta Universitatis Upsaliensis.
Förlag: Uppsala: Universitetsbiblioteket
Distributör: Universitetsbiblioteket, Box 510, 75120 Uppsala, Sverige
Utgivningsår: 2003
Tillgänglig: 2003-04-14
Sidor: 76
Serie: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1246
ISBN: 91-554-5588-3
Förlag: Uppsala: Universitetsbiblioteket
Distributör: Universitetsbiblioteket, Box 510, 75120 Uppsala, Sverige
Utgivningsår: 2003
Tillgänglig: 2003-04-14
Sidor: 76
Serie: Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1246
ISBN: 91-554-5588-3
LISTA ÖVER DELARBETEN
1. Appelberg, Jonas ; Sundström, Gunnar: Ventilatory response to CO2 in patients with snoring, obstructive hypopnoea and obstructive apnoea. Clinical Physiology, 17(1997), 497-507 (published)
2. Appelberg, Jonas ; Nordahl, Gunnar ; Janson, Christer: Lung volume and its correlation to nocturnal apnoea and desaturation. Respiratory Medicine, 94(2000), 233-239 (published)
3. Appelberg, Jonas ; Pavlenko, Tatjana ; Bergman, Henrik ; Rothen, Hans Ulrich ; Hedenstierna, Göran: Lung aeration during sleep. (submitted)
4. Appelberg, Jonas ; Janson, Christer ; Lindberg, Eva ; Weisby-Enbom, Lena ; Hedenstierna, Göran: Lung aeration during sleep in patients with obstructive sleep apnea. (manuscript)
REFERENS TILL DENNA SIDA
Appelberg, Jonas (2003). Ventilation and Lung Volume During Sleep and in Obstructive Sleep Apnea. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3363 (2003-04-14)